A2 Photonic Sensors is pleased to announce its participation in the 9th International BioProScale Symposium, taking place 20–22 April 2026 at the Langenbeck-Virchow-Haus in Berlin, Germany. This symposium brings together leading academics and industry specialists to advance the understanding of bioprocess scaling — from small-scale models to industrial-scale fermenters — with a strong focus on process heterogeneities, robustness, and analytics.
Optical Probes for Gas–Liquid Characterization in Bioreactors
Mass transfer and bubble dynamics are at the heart of bioprocess performance. Whether in stirred tank bioreactors, bubble columns, or airlift reactors, the ability to accurately characterize the local gas–liquid flow is essential for understanding oxygen supply to microbial or mammalian cultures, validating scale-up models, and optimizing aeration strategies.
Our M2 Bubble Analyzer provides local, continuous measurements of key hydrodynamic parameters — bubble size/velocity distributions, gas hold-up — directly within the reactor volume. These data points complement volumetric kLa measurements and CFD simulations, giving bioprocess engineers a finer picture of the spatial heterogeneities that drive cell-to-bioreactor interactions across scales.
Supporting Scale-Up and Process Analytical Technology (PAT)
Scaling bioprocesses reliably requires more than a good mixing time estimate. Understanding how local gas dispersion evolves between a 2 L laboratory vessel and a 2,000 L industrial fermenter is a persistent challenge — one that our optical probes are designed to help address. By providing spatially resolved bubble data at both pilot and production scale, the M2 Bubble Analyzer fits naturally into the PAT framework promoted by the BioProScale community: integrating sensors and data into real-time process monitoring, scale-down model design, and control strategy development.
Our instruments deliver repeatable measurements across the full range of aeration conditions encountered in bioprocessing, including high-viscosity broths and varying cell densities — conditions that are notoriously difficult to characterize with standard sensing approaches.
Meet Us at BioProScale 2026
Come and visit our booth at the exhibition to discuss your experimental needs and discover how our optical measurement solutions can support your bioprocess development and scale-up projects. We are equally happy to explore applications not yet covered by our current instrument range and to work with you on tailored measurement solutions for your specific reactor geometry or process conditions.
BioProScale 2026 marks our first participation in this symposium series — a deliberate step as we engage more actively with the bioprocess engineering community, where we see a growing need for local, in-situ hydrodynamic characterization tools. We look forward to meeting researchers, process engineers, and industrial practitioners in Berlin, and to contributing to the conversation around instrumentation for next-generation bioprocesses.